English Summary
CORRELATION BETWEEN SERUM
FERRITIN IN THIRD TRIMESTER
PREGNANCY WITH BIRTH WEIGHT
Najoan Nan Warouw, Sugiarto
Wiriadinata*
Dept of Obstetrics and Gynecology,
*Dept of Pediatrics, Faculty of
Medicine, Sam Ratulangi University,
Manado, Indonesia
Background : Iron deposit can be
measured by ferritin serum level.
Until now, study on the correlation
between iron deficiency anemia
and iron status in third trimester
pregnancy, is still very limited.
Objective: To examine iron status
in third trimester pregnant women
who later delivered low birth weight
babies; correlation between social
economic status with ferritin serum
level in third trimester pregnancy
and the correlation between iron
supplementation with ferritin serum
level of pregnant women.
Design: Cross Sectional Analytical
Study
Setting: Hemoglobin level was
measured with cyanmethemo-
globin method and ferritin serum
was measured by immunochemi-
luminescence (ICMA) method
using IMMULITE 2000 (at Prodia
laboratory)
Participants: 30 pregnant women
who later delivered low birth weight
babies below 2500 grams.
Outcome measures: Hemoglobin
and ferritin serum level.
Results: Hemoglobin level of low
birth weight babies in this study
was 17,137 (SB 2,083) g/dl with
ferritin serum level about 338,30
(SB 271,58) ng/ml. Correlation
coefficient was 0,538 with
significant value 0,002 (p < 0,01).
Using cross sectional analysis,
ferritin serum level of pregnant
women was very significantly
correlated with ferritin serum level
of low birth weight babies (p <
0,01); Social economic status
significantly correlated with ferritin
serum level of pregnant women (p
< 0,05); Iron supplemention very
significantly correlated with ferritin
serum level of pregnant women (p
< 0,01).
Conclusion : There is a significant
correlation between ferritin serum
level in third trimester pregnancy
and ferritin serum level in their low
birth weight babies; between
social economic status of preg-
nant women and their babies' birth
weight, and between iron supple-
mention and ferritin serum level
among pregnant women.
Cermin Dunia Kedokt.2004; 145; 5-15
nnw, swi
URIC ACID LEVEL AS A PREDICTOR
FOR PRETERM SEVERE PREECLAMP-
SIA MANAGEMENT
Ferry Armanza, Made Kornia
Karkata
Dept. of Obstetrics and Gyneco-
logy ,Faculty of Medicine, Udaya-
na University/Sanglah Hospital, Bali,
Indonesia
Introduction : Preeclampsia/
eclampsia is still the main cause of
maternal and perinatal mortality;
but the choice between
conservative and active manage-
ment for severe preeclampsia in
preterm pregnancy is still
unsettled. On the other hand,
serum uric acid (SUA) level can be
used as a predictor for
preeclampsia in later pregnancy
and for maternal and perinatal
outcome in preeclampsia cases.
High SUA may worsen maternal
and perinatal outcome.
Objective : To determine the cut-
off point of SUA for use in choosing
either conservative or active
treatment in the management of
severe preeclampsia in preterm
pregnancy.
Method : Observational study on
severe preeclampsia cases in
preterm pregnancy (21-36 weeks)
managed conservatively in De-
partment of Obstetrics and Gyne-
cology Sanglah Hospital Denpa-
sar. SUA level was obtained from
each sample. Conservative treat-
ment was considered failed if
pregnancy was terminated or in
case of IUFD before 37 weeks of
pregnancy.
Results : Among 65 samples the
mean level of SUA was 7,749
mg/dL (SD 1,31). On conservative
treatment, 44 cases (67,7%)
failed. Using sensitivity, specificity
value and ROC curve, the cut-off
point of SUA was determined at
7,60 mg/dL. Among 41 cases with
SUA 7,60 mg/dL, 38 cases
(92,7%) failed; and from 24 cases
with SUA < 7,60 mg/dL, 6 cases
(25,0%) failed - sensitivity 86,36% ;
specificity 85,71% ; positive pre-
dictive value 92,68% and nega-
tive predictive value 75% (PR :
3,71 ; CI 95% : 1,844 7,453 ; ² :
31,710 ; p : 0,001).
Among 41 cases with SUA 7,60
mg/dL) there were 7 cases (17,1%)
with birth weight (BW) < 1500 g.,
24 cases (58,5%) with BW 1500
2499 g.and 10 cases (24,4%) with
BW 2500 g. And from 24 cases
with SUA < 7,60 mg/dL there were
2 cases (8,3%) with BW < 1500 g.,
7 cases (29,2%) with BW 1500
2499 g. and 15 cases (62,5%) with
BW 2500 g. The difference was
significant (² : 9,290 ; p : 0,010).
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Cermin Dunia Kedokteran No. 146, 2005
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