English Summary
ASTHMA BRONCHIALLE TREAT-
MENT WITH SLOW-RELEASE ONCE-
A-DAY THEOPHYLLINE
Tjandra Yoga Aditama, Hadiarto
Mangunnegoro, Mukhtar Ikhsan
Dept. of Pulmonology, Faculty of Medi-
cine, University of Indonesia/Persa-
habatan Hospital, Jakarta, Indonesia
The efficacy and tolerability of
Once-A-Day Theophylline (Piras-
min-Retard®) was compared with
theophylline 4 x 150mg in across-
over study involving 30 patients
with asthma bronchiole.
Theophylline plasma levels
were essayed on day-7 (after 7-
day administration of Theophyl-
line 4 x 150 mg); on day-14 (after
7-day administration of Pirasmin-
Retard® 650 o.d) and on day-21
(after 14-day administration of
Pirasmin-Retard®). The means
were day-7 : day-14 = 2.6 ± 6.2
mcg: 7.0 ± 7.7 mcg (p = 0,001),
and day-7 : day-21 2.9 ± 5.7
mcg : 7.3 ± 6.9 mcg (p < 0.001).
Pulmonary function test (FEV-
1,FVC,PFR) were performed and
the clinical symptoms (cough,
disturbances of activities and
sleeps. wheezing) were also
evaluated.
The result confirmed that the
administration of Pirasmin-Re-
tard® (Once-A-Day Theophylline)
provided significant better theo-
phylline plasma levels. The pul-
monary function measurement
(FVC and FEV increased very
significantly but there were no
significant difference between
group A and B.
Cermin Dunia Kedokt, 1995; 101:21-4
Tya, Hm, Mi
THE CLINICAL EFFICACY OF
CEFIXIME ON NON TUBERCULOUS
LOWER RESPIRATORY TRACT IN-
FECTIONS
Djoko Trihadi, Hermawati Ananta
Rahardja
Pulmonary Disease Treatment Centre, Se-
marang, Indonesia
Cefixime, one of the new third
generation oral cephalosporin
antibiotic, was evaluated for
safety and efficacy in the treat-
ment of 37 patients with non-
tuberculous lower respiratory
tract infections. Cefixime was
given to 20 patients with pneu-
monia, 10 patients with acute
bronchitis and 7 patients with
infected bronchiectasis. Each
patient had sputum culture
before and after therapy and was
treated with 4 - 14 consecutive
days course of Cefixime 3-6mg/
kg body weight twice daily. Cli-
nical efficacy was evaluated
according to the symptom
improvement (cough, fever,
sputum, dyspnoe) laboratory
findings and microbiologic results.
All patients were evaluated for
safety and efficacy.
The results were as follow:
1. 34 patients had good respon-
ses, with improvement of symp-
toms after taking Cefixime.
2. Clinical efficacy was 91,89% in
37 Nontuberculous Lower
Respiratory Tract infections;
cured: 20 (54,06%), improved:
14 (37,83%) and failure 3
(8,11%).
3. Safety was monitored in all
cases and there were no
cases of any complaints as side
effects, no significant abnor-
mal findings on laboratory test
during treatment.
4. Sputum culture resulted in 37
isolated pathogen with 10 diffe-
rent strains and was eradi-
cated in 94,59% after taking
Cefixime with variables MIC
level, while 2 cases were resis-
tant.
Cermin Dunia Kedokt. 1995; 101: 44-7
Dt, Har
THE ROLE OF MOTHERS IN THE
MANAGEMENT OF ARI IN WEST
JAVA
Enny Muchlastriningsih
Communicable Diseases Research
Center, Health Research and Develop-
ment Board, Department of Health,
Jakarta, Indonesia
A study on the effect of health
education on Acute Respiratory
Infection (ARI) among mothers
having five years old children
had been conducted in two
districts: Cianjur and Sumedang,
West Java (October 1992 Ja-
nuary 1993).
In Cianjur District where health
education was given there was
an increase of mothers know-
ledge. management and atti-
tude which positively support
the recovery of pneumonia
compared to the control district
Sumedang.
Cermin Dunia Kedokt. 1995, 101:50-2
Em
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