Alamat Redaksi
Gedung KALBE
Jl. Letjen. Suprapto Kav. 4
Cempaka Putih, Jakarta 10510
Tlp: 021-4208171
Fax: 021-4287 3685
E-mail: cdk.redaksi@yahoo.co.id
Web: http://www.kalbe.co.id/cdk
Milis: http://groups.yahoo.com/group/milisCDK
Nomor Ijin
151/SK/DITJEN PPG/STT/1976 Tanggal 3 Juli 1976
Penerbit
Kalbe Farma
Pencetak
PT. Temprint
Susunan Redaksi
Ketua Pengarah
Dr. Boenjamin Setiawan, PhD
Pemimpin Umum
Dr. Erik Tapan
Ketua Penyunting
Dr. Budi Riyanto W.
Manajer Bisnis
Nofa, S.Si, Apt.
Dewan Redaksi
Prof. Dr. Sjahbanar Soebianto Zahir, MSc.
Dr. Michael Buyung Nugroho
Dr. Karta Sadana
Dr. Sujitno Fadli
Drs. Sie Djohan, Apt.
Ferry Sandra, Ph.D.
Budhi H. Simon, Ph.D.
Tata Usaha
Dodi Sumarna
CDK 168/vol.36 no.2/Maret - April 2009
79
Redaksi Kehormatan
Prof. Drg. Siti Wuryan A Prayitno, SKM, MScD, PhD
Bagian Periodontologi, Fakultas Kedokteran Gigi Universitas Indonesia, Jakarta
Prof. Dr. Abdul Muthalib, SpPD KHOM
Divisi Hematologi Onkologi Medik
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/
RSUPN Dr. Cipto Mangunkusumo, Jakarta
Prof. Dr. Djoko Widodo, SpPD-KPTI
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonsia/
RSUPN Dr. Cipto Mangunkusumo, Jakarta
Prof. DR. Dr. Charles Surjadi, MPH
Pusat Penelitian Kesehatan Unika Atma Jaya Jakarta
Prof. DR. Dr. H. Azis Rani, SpPD, KGEH
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/
RSUPN Dr. Cipto Mangunkusumo, Jakarta
Prof. DR. Dr. Sidartawan Soegondo, SpPD, KEMD, FACE
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/
RSUPN Dr. Cipto Mangunkusumo, Jakarta
DR. Dr. Abidin Widjanarko, SpPD-KHOM
Fakultas Kedokteran Universitas Indonesia/RS Kanker Dharmais, Jakarta
DR. Dr. med. Abraham Simatupang, MKes
Bagian Farmakologi, Fakultas Kedokteran Universitas Kristen Indonesia, Jakarta
Prof. Dr. Sarah S. Waraouw, SpA(K)
Dekan Fakultas Kedokteran Universitas Sam Ratulangi, Manado
Prof. DR. Dr. Rully M.A. Roesli, SpPD-KGH
Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran/
RSUP Dr. Hasan Sadikin, Bandung
Dr. Aucky Hinting, PhD, SpAnd
Bagian Biomedik Fakultas Kedokteran Universitas Airlangga Surabaya
Prof. DR. drg. Hendro Kusnoto, SpOrt.
Laboratorium Ortodonti Fakultas Kedokteran Gigi Universitas Trisakti, Jakarta
DR. Dr. Yoga Yuniadi, SpJP
Departemen Kardiologi dan Kedokteran Vaskular FKUI/
Pusat Jantung Nasional Harapan Kita, Jakarta
Prof. DR. Dra. Arini Setiawati
Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia, Jakarta
Prof. Dr. Faisal Yunus, PhD, SpP(K)
Departemen Pulmonologi & Ilmu Kedokteran Respirasi Fakultas Kedokteran
Universitas Indonesia/SMF Paru RS Persahabatan, Jakarta
Prof. DR. Dr. Rianto Setiabudy, SpFK
Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia, Jakarta
Dr. R.M. Nugroho Abikusno, MSc., DrPH
Fakultas Kedokteran Universitas Trisakti, Jakarta
Prof. DR. Dr. Wimpie Pangkahila, SpAnd, FAACS
Fakultas KedokteranUniversitas Udayana Denpasar, Bali
Prof. DR. Dr. Ignatius Riwanto, SpB(K)
Bagian Bedah Fakultas Kedokteran Universitas Diponegoro/
RS Dr. Kariadi, Semarang
Dr. Tony Setiabudhi, SpKJ, PhD
Universitas Trisakti/ Pusat Kajian Nasional Masalah Lanjut Usia, Jakarta
Prof. DR. Samsuridjal Djauzi, SpPD, KAI
Sub Dept. Alergi-Imunologi, Dept. Ilmu Penyakit Dalam Fakultas Kedokteran
Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta
Dr. Prijo Sidipratomo, SpRad(K)
Departemen Radiologi FKUI/RSUPN Dr. Cipto Mangunkusumo, Jakarta
Prof. DR. Dr. Johan S. Masjhur, SpPD-KEMD, SpKN
Departemen Kedokteran Nuklir Fakultas Kedokteran Universitas Padjadjaran/
RSUP Dr. Hasan Sadikin, Bandung
Dr. Hendro Susilo, SpS(K)
Dept. Neurologi Fakultas Kedokteran Universitas Airlangga/RS Dr. Soetomo,
Surabaya
Prof. DR. Dr. Darwin Karyadi, SpGK
Institut Pertanian Bogor, Bogor, Jawa Barat
Dr. Ike Sri Redjeki, SpAn KIC, M.Kes
Bagian Anestesiologi & Reanimasi Fakultas Kedokteran Universitas Padjadjaran/
RSUP Dr. Hasan Sadikin, Bandung
ISSN: 0125-913 X
http://www.kalbe.co.id/cdk
ENGLISH SUMMARY
CDK 168/vol.36 no.2/Maret - April 2009
Vitamin D Deficiency
among Geriatrics :
mechanism, implication
and therapy
Andreas Soejitno, RA Tuty Kuswardhani
Geriatrics Subdivision, Dept. of Internal Medicine,
Faculty of Medicine,Udayana University/Sanglah
General Hospital, Denpasar, Bali, Indonesia
V
itamin D has an essential role in calcium-
phosphorus metabolism and regulation of para-
thyroid hormone (PTH), thus maintaining bone
integrity through mineralization and inhibit
degenerative process (osteoporosis) and fractures.
Various trials and observational studies demons-
trate vitamin D effect in reducing cancer risk,
infectious and autoimmune diseases, and cardio-
vascular disease.
However, deficiency in vitamin D is common and
the prevalence is expected to reach over one
billion people worldwide. In elderly, deficiency is
frequently diagnosed in geriatric outpatients and
the housebound. Deficient status is diagnosed
if serum 25-hydroxyvitamin D [25-(OH)D] <
20 ng/mL (50 nmol/L), where as 21-29 ng/mL
(52 to 72 nmol/L) is considered to be vitamin
D insufficiency.
This article elucidates and discusses subtle
distinctions in vitamin D-deficiency and/or
insufficiency therapy for elderly in comparison
to children and adults.
Keywords: Deficiency, vitamin D, mechanism,
implication, therapy, elderly.
CDK 2009; 36(2) : 81-83
Effect of Angkak on
Total Blood Cholesterol
Level in White Mice
(Rattus norvegicus)
Christina Dian Anggraeni, Jarot Subandono*,
Kustiwinarni*
Student, *Lecturer, Biochemistry Lab.,
Faculty of Medicine, Sebelas Maret University,
Those substances are believed as a lowering
total blood cholesterol agent. This research
is to study the effect of red yeast rice on total
blood cholesterol levels in Rattus norvegicus.
This study was an experimental research
design, used posttest-only control group design.
Subjects of research were Rattus norvegicus,
Wistar strain, male, 3 months, 200 grams.
By random sampling technique, data were
collected from 35 Rattus norvegicus.
Using sign test with _=0.05, it is concluded
that the effect of red yeast rice in lowering
blood total cholesterol level is significant.
Key words: red yeast rice, total blood choles-
terol levels, Rattus norvegicus.
CDK 2009; 36(2) : 94-95
This study used coconut water and coconut
milk which contain albumin as neutralizer. Such
compound can kill histidine bacteria, preventing
histamine production. Other components of
coconut water are growth elements, trace
elements, carbohydrate, and small amounts
of vitamins.
Results indicated that sea water fish treated
with coconut water and coconut milk still have
bacteria and non pathogenic fungi. However,
its histamine content was below threshold
(25 ppm). After treated with coconut water
and coconut milk, Tongkol contained 11,99
ppm and 11,39 ppm of histamine, and
Kembung contained 9,43 ppm and 9,30 ppm
of histamine.
CDK 2009; 36(1) : 102-104
Potency of Coconut
Water and Coconut
Milk as Seawater Fish
Poison Neutralizer
Nunik Siti Aminah, Supraptini,
Enny W. Lestari, Soejitno, Sukijo
Health Ecology Research Center, Health Research
and Development Board, Department of Health,
Jakarta, Indonesia
80
R
ed yeast rice is a product of rice fermentation
with various strains of Monascus purpureus
yeast. Red yeast rice contains monakolin K,
phytosterol, PUFA, fiber and niacin.
S
ea water fish such as Tongkol and Kembung
can contain more than 100 ppm histamine that
can be poisonous.